Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

AM are the first responders to infections and inflammatory insults in the lung. We and others have reported that lung resident macrophages are dependent on glycolysis to respond to LPS (Lavrich et al., 2018) or Mtb (Gleeson et al., 2016; Gleeson et al., …

Eisai Closes Door on Lorcaserin Program for Dravet Syndrome

Eisai has discontinued 2 clinical trials for lorcaserin in Dravet syndrome due to recruitment challenges in this rare epilepsy. The affected trials include the phase 3 MOMENTUM 1 study (NCT04572243) and MOMENTUM 2 extended access program, as first reported …

Live updates as roads closed around King Power Stadium due to building fire

Multiple fire crews on scene at Leicester building fire A video seen by LeicestershireLive shows several fire crews responding to the building fire on Burnmoor Street. At least eight fire appliances and an aerial ladder platform are currently at the scene. …

J&J appoints Shawn Millerick to lead vision care unit in the Americas

Shawn Millerick, Johnson & Johnson’s president of vision care, Americas Permission granted by Johnson & Johnson   Name: Shawn Millerick New title: President, vision care, Americas, Johnson & Johnson Previous title: Principal and advisor, The …

Forget protein—This is the nutrient kids need

It’s a concern we hear from parents all the time: “My son refuses to eat meat, and I’m really worried he isn’t getting enough protein.” This is a common worry among families, but kids often need much less protein than parents think. In fact, most parents …

Non-Pharmacological Strategies for Psoriasis Comorbidities: The Dermatologist’s Role

Photo Credit: SurfUpVector Amy Huang, MD, spoke with Physician’s Weekly about the non-pharmacologic options for managing comorbidities in patients with psoriasis. At this year’s Fall Clinical Dermatology Conference, numerous presenters discussed the …

A Case for Expanding the Differential Diagnosis of Cardiac Sarcoidosis

A case from CHEST 2024 shows that cardiac sarcoidosis should be considered in patients aged less than 65 who have unexplained high-grade atrioventricular block. “Clinically significant cardiac sarcoidosis (CS) is estimated to be seen in 5% of sarcoidosis …

Help The Myton Hospices raise £25,000 in just 24 hours

The Myton Hospices is hoping to perform something of a Christmas miracle on Giving Tuesday and raise an amazing £25,000 in just 24 hours so more people in Coventry and Warwickshire can access a Hospice Bed. The Myton Hospices is hoping to perform something …

Opinion: The state of rev cycle mgmt. in healthcare—and what AI can do to change it

India's Zika Outbreak Intensives, 63 Pregnant Women Infected

(Vax-Before-Travel)Since 2016, the Zika virus (ZIKV) has been reported in India's 16 different states/union territories. According to local media, the ongoing Zika outbreak in the state of Maharashtra, India, has significantly expanded this year. …